New insights into procathepsin D in pathological and physiological conditions

Pathological conditions re-shape physiological Tregs into pathological Tregs

CD4+FOXP3+ regulatory T cells (Tregs) are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance, controlling acute and chronic inflammation, allergy, autoimmune diseases, and anti-cancer immune responses. Over the past 20 years, significant progress has been made since Tregs were first characterized in 1995. Many concepts and principles regarding Tregs g...

Editorial: Cardiac Remodeling: New Insights in Physiological and Pathological Adaptations

new insights into vegf-a alternative splicing: key regulatory switching in the pathological process

vascular endothelial growth factor (vegf-a) is one of the most important regulatory factors in pathological and physiological angiogenesis. alternative splicing is a complicated molecular process in vegf-a gene expression which adds complexity to vegf-a biology. among all vegf-a exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic vegf-xxx to ant...

Citrullination under physiological and pathological conditions.

Citrullination, one of the enzymatic posttranslational modifications has become a hot topic of recent research as it is involved in various physiological and pathological processes. Antibodies against citrullinated proteins called anti-citrullinated protein antibodies, are the hallmark (diagnostic and prognostic factors) of rheumatoid arthritis, and are specific for the disease. Citrullination ...

Physiological insights into Shechita.

The Government recently announced that it intends to reject a recommendation by the Farm Animal Welfare Council that all animals should be stunned before slaughter (see VR, April 10, p 446). In this Viewpoint article, Dr Stuart Rosen discusses physiological aspects of Shechita, the Jewish method of religious animal slaughter. He outlines the religious context and describes the act of Shechita. ...