Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression
نویسندگان
چکیده
منابع مشابه
Shift work, night work, and the risk of prostate cancer
BACKGROUND Epidemiology studies suggested that shift work or night work may be linked to prostate cancer (PCa); the relationship, however, remains controversy. METHODS PubMed, ScienceDirect, and Embase (Ovid) databases were searched before (started from the building of the databases) February 4, 2017 for eligible cohort studies. We pooled the evidence included by a random- or fixed-effect mod...
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BACKGROUND Night shift work has been associated with higher risks of breast and endometrial cancer, but few studies have evaluated associations with other reproductive cancers. METHODS We examined the association between rotating night shift work and risk of ovarian cancer during 20 years of follow-up in 181,548 women participating in two large cohort studies, the Nurses' Health Study (NHS) a...
متن کاملNight shift work and the risk of endometrial cancer.
Melatonin has several oncostatic properties, including possible anti-estrogenic and anti-aromatase activity, and seems to be linked with fat metabolism. Night workers have lower levels of melatonin, which may predispose them to develop cancer. Endometrial cancer risk is influenced significantly by hormonal and metabolic factors; therefore, we hypothesize that night workers may have an increased...
متن کاملAssociations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer.
INTRODUCTION Insulin, insulin-like growth factor (IGF), and IGF binding protein (IGFBP) are involved in cell growth and proliferation and are thought to be important in the etiology of colorectal cancer. We hypothesize that genetic polymorphisms of insulin receptor substrates (IRS-1 and IRS-2), IGF-I, and IGFBP-3 alter colorectal cancer risk because of their roles in the insulin-related signali...
متن کاملNight shift work, light at night, and risk of breast cancer.
BACKGROUND Exposure to light at night may increase the risk of breast cancer by suppressing the normal nocturnal production of melatonin by the pineal gland, which, in turn, could increase the release of estrogen by the ovaries. This study investigated whether such exposure is associated with an increased risk of breast cancer in women. METHODS Case patients (n = 813), aged 20-74 years, were ...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2019
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-19-0325