Nitazoxanide for the Treatment of Clostridium difficile Colitis
نویسندگان
چکیده
منابع مشابه
Nitazoxanide versus metronidazole for Clostridium difficile-associated colitis.
To the Editor—Reports of increased incidence and severity of Clostridium difficile–associated colitis have stimulated interest in the search for additional treatment options for this clinical problem. Musher et al. [1] recently reported the results of a noninferiority study that compared metronidazole with nitazoxanide for the treatment of C. difficile colitis. The authors concluded that “nitaz...
متن کاملClostridium difficile colitis
Bacteriology and Pathogenesis Clostridium difficile is a Gram-positive sporeforming anaerobic bacillus, which is found in the stool flora of 25-80% of healthy infants but rarely in the stool of healthy adults and children over the age of 12 months. Ingested spores of C. difficile survive the gastric acid barrier and germinate in the colon. Colonization of the adult intestinal tract occurs when ...
متن کاملClostridium difficile-associated colitis.
OBJECTIVE To review the basic microbiology, pathogenesis of disease, and diagnosis of the nosocomial pathogen Clostridium difficile and to examine therapies recommended by the Canadian Task Force on Preventive Health Care. QUALITY OF EVIDENCE MEDLINE: was searched using MeSH headings. Controlled trials for therapy were sought, but case-control studies and observational reviews were included. ...
متن کاملProbiotics for treatment of Clostridium difficile-associated colitis in adults.
BACKGROUND Probiotics are live microorganisms consisting of non-pathogenic yeast and bacteria that are believed to restore the microbial balance of the gastrointestinal tract altered by infection with Clostridium difficile (C. difficile). OBJECTIVES To assess the efficacy of probiotics in the treatment of antibiotic associated C. difficile colitis. SEARCH STRATEGY The databases MEDLINE, EMB...
متن کاملClostridium difficile colitis that fails conventional metronidazole therapy: response to nitazoxanide.
OBJECTIVES Clostridium difficile-associated disease has increased in incidence and severity. Recommended treatments include metronidazole and vancomycin. Recent investigations, however, document the failure of metronidazole to cure a substantial proportion of patients with Clostridium difficile colitis, but oral administration of vancomycin raises concerns over selection of antibiotic-resistant...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2006
ISSN: 1058-4838,1537-6591
DOI: 10.1086/506351