Nitric oxide synthase activity in hyperthyroid and hypothyroid rats
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چکیده
منابع مشابه
Nitric oxide synthase activity in hyperthyroid and hypothyroid rats.
OBJECTIVE Thyroid disorders are accompanied by important changes in haemodynamic and cardiac functions and renal sodium handling. Since nitric oxide (NO) plays a crucial role in regulating vascular tone and renal sodium excretion, the present paper was designed to determine whether changes in the activity of NO synthase (NOS) participate in the cardiovascular and renal manifestations of thyroid...
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Objective(s):Some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. Incidence of these condition increases with aging. On the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (NOS) activity is also altered in diabetes. In this study, modification in the enzyme activity associated with aging a...
متن کاملAtrial angiotensinase activity in hypothyroid, euthyroid, and hyperthyroid rats.
Thyroid dysfunction produces marked cardiovascular responses. Hypothyroidism and hyperthyroidism cause important changes in the circulating renin-angiotensin system (RAS). Modifications in cardiac RAS have also been involved in cardiovascular alterations. Studies have revealed that thyroid hormones activate some components of cardiac RAS. Angiotensin (Ang) peptides are regulated by the activity...
متن کاملresis response in hyperthyroid and hypothyroid rats
1. Renal responses to changes in renal perfusion pressure were studied in anaesthetized hyperthyroid (thyroxine, 300 pg day' kg') and hypothyroid (methimazole, 0.03% via drinking water) rats to determine whether an abnormality in the pressurediuresisnatriuresis phenomenon is involved in the resetting of kidney function in these disorders. 2. There were no significant differences between control...
متن کاملNeuronal expression of inducible nitric oxide synthase in hypothyroid rat.
OBJECTIVES The expression of iNOS mRNA and protein levels was studied in hypothyroid rat cerebral cortex during early days after postnatal life. METHOD The homogenate of the cerebral cortex was examined using Real-time reverse transcription polymerase chain reaction (real-time RT PCR) and Western blot analysis. RESULT ΔCt in hypothyroid group on day 7, 14, 21 was 18.89±0.92, 18.83±0.99, 16....
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2002
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1470117