Noisy protein sorting
نویسندگان
چکیده
منابع مشابه
Sorting from Noisy Information
This paper studies problems of inferring order given noisy information. In these problems there is an unknown order (permutation) π on n elements denoted by 1, . . . , n. We assume that information is generated in a way correlated with π. The goal is to find a maximum likelihood π given the information observed. We will consider two different types of observations: noisy comparisons and noisy o...
متن کاملProtein secretion: Sorting sweet sorting
How are proteins sorted to different destinations in eukaryotic cells? Until recently, it was generally thought that the constitutive flow of proteins to the cell surface occurs by default, and that proteins simply accumulate carbohydrate modifications as they pass sequentially through each compartment along the secretory pathway [1]. This hypothesis was supported by studies showing that inhibi...
متن کاملMinimax Rates and Efficient Algorithms for Noisy Sorting
There has been a recent surge of interest in studying permutation-based models for ranking from pairwise comparison data. Despite being structurally richer and more robust than parametric ranking models, permutation-based models are less well understood statistically and generally lack efficient learning algorithms. In this work, we study a prototype of permutation-based ranking models, namely,...
متن کاملPalmitoylation-dependent protein sorting
S-palmitoylation is a posttranslational modification that regulates membrane-protein interactions. However, palmitate is more than just a hydrophobic membrane anchor, as many different types of protein are palmitoylated, including transmembrane proteins. Indeed, there is now compelling evidence that palmitoylation plays a key role in regulating various aspects of protein sorting within the cell.
متن کاملProtein sorting: Recognizing mitochondrial presequences
The mitochondrial protein import machinery specifically recognizes many different preproteins lacking a consensus sequence. The three-dimensional structure of an import receptor complexed to an amino-terminal targeting 'presequence' provides exciting insight into the molecular mechanism of signal recognition.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 1999
ISSN: 1087-0156,1546-1696
DOI: 10.1038/13618