Non-coding genetic variation in cancer
نویسندگان
چکیده
منابع مشابه
The Role of Long Non-Coding RNAs in Ovarian Cancer
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Our current understanding of how natural genetic variation affects gene expression beyond well-annotated coding genes is still limited. The use of deep sequencing technologies for the study of expression quantitative trait loci (eQTLs) has the potential to close this gap. Here, we generated the first recombinant strain library for fission yeast and conducted an RNA-seq-based QTL study of the co...
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It has been found that the majority of disease-associated genetic variants identified by genome-wide association studies are located outside of protein-coding regions, where they seem to affect regions that control transcription (promoters, enhancers) and non-coding RNAs that also can influence gene expression. In this review, we focus on two classes of non-coding RNAs that are currently a majo...
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ژورنال
عنوان ژورنال: Current Opinion in Systems Biology
سال: 2017
ISSN: 2452-3100
DOI: 10.1016/j.coisb.2016.12.017