Non-Intercalative Triterpenoid Inhibitors of Topoisomerase II: A Molecular Docking Study
نویسندگان
چکیده
منابع مشابه
Non-Intercalative Triterpenoid Inhibitors of Topoisomerase II: A Molecular Docking Study
Theoretical flexible docking studies were carried out on a number of triterpenoids previously shown to be inhibitors of topoisomerase II in order to assess the nature of binding of these non-intercalative inhibitors to the enzyme. The molecular docking results suggest that most of the triterpenoids preferentially bind to the DNA binding site of topoisomerase II, while a few also bind to the ATP...
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ژورنال
عنوان ژورنال: The Open Bioactive Compounds Journal
سال: 2008
ISSN: 1874-8473
DOI: 10.2174/1874847300801010013