Non-Obese Type 2 Diabetic Rat Models-GK Rat and SDT Rat
نویسندگان
چکیده
منابع مشابه
Diabetic Complications in Obese Type 2 Diabetic Rat Models
We overviewed the pathophysiological features of diabetes and its complications in obese type 2 diabetic rat models: Otsuka Long-Evans Tokushima fatty (OLETF) rat, Wistar fatty rat, Zucker diabetic fatty (ZDF) rat and Spontaneously diabetic Torii (SDT) fatty rat. Pancreatic changes with progression of diabetes were classified into early changes, such as islet hypertrophy and degranulation of β ...
متن کامل(SDT Fatty) Rat: A Novel Model of Obese Type 2 Diabetes
Diabetic animal models play critical roles in the elucidation of the mechanisms of diabetes mellitus and the complications, and in the development of novel drugs as treatments. Spontaneously Diabetic Torii Lepr fa (SDT fatty) rat, established by introducing the fa allele of the Zucker fatty rat into SDT rat genome, is a new model of obese type 2 diabetes. We have investigated the characteristic...
متن کاملIL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat.
Recent studies suggest an inflammatory process, characterized by local cytokine/chemokine production and immune cell infiltration, regulates islet dysfunction and insulin resistance in type 2 diabetes. However, the factor initiating this inflammatory response is not known. Here, we characterized tissue inflammation in the type 2 diabetic GK rat with a focus on the pancreatic islet and investiga...
متن کاملMarked increase in white adipose tissue blood perfusion in the type 2 diabetic GK rat.
The aim of the present study was to evaluate and cor-relate islet to brown and white adipose tissue (WAT) blood perfusion in one obese rat and one nonobese rat with type 2 diabetes (obese Zucker [OZ] and GK rats, respectively). We measured blood perfusion with a microsphere technique in anesthetized animals and subsequently estimated the blood flow to seven different WAT depots and brown adipos...
متن کاملMicroRNA expression profiling in diabetic GK rat model.
MicroRNAs (miRNAs), which are a newly identified class of small single-stranded non-coding RNAs, regulate their target genes via post-transcriptional pathway. It has been proved that miRNAs play important roles in many biological processes. To better understand miRNA function on type 2 diabetes, we used an oligonucleotide microarray to monitor miRNA expression profiles of Goto-Kakizaki (GK) and...
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ژورنال
عنوان ژورنال: Open Journal of Animal Sciences
سال: 2018
ISSN: 2161-7597,2161-7627
DOI: 10.4236/ojas.2018.84030