NON-UNIFORM PULMONARY DIFFUSION AS DEMONSTRATED BY THE CARBON MONOXIDE EQUILIBRATION TECHNIQUE: MATHEMATICAL CONSIDERATIONS*

Non-uniform pulmonary diffusion as demonstrated by the carbon monoxide equilibration technique: experimental results in man.

Available evidence indicates that pulmonary diffusion is distributed in a non-uniform manner throughout the lung; the pertinent literature was reviewed briefly in the preceding paper of this series (1). Conventional methods for measuring the pulmonary diffusing capacity do not allow a quantitative assessment of this non-uniformity, and, in the presence of uneven diffusion, may yield erroneous v...

Mathematical Model for Carbon Monoxide Diffusion in Man

Facilitated diffusion. The case of carbon monoxide.

An application of a singular perturbation method to the case of carbon monoxide similar to that used previously for the case of oxygen (MURRAY, J. D., Proc. Roy. SOC. London B Biol. Sci., 178, 95 (1971)) shows that the absence of any observed facilitation of diffusion of this ligand by either hemoglobin or myoglobin in all of the experiments so far performed results from the very high affinity ...

Mathematical models of the uptake of carbon monoxide on hemoglobin at low carbon monoxide levels.

Coburn's differential equation for the uptake of carbon monoxide by hemoglobin and two particular types of solution of this equation were considered and the solutions verified for a group of healthy adults consisting of 73 nonsmoking pedestrians or car passengers exposed to low levels of carbon monoxide as experienced in the city of Lyon. The CO levels at the breathing level and the walking spe...

Delayed restricted diffusion in carbon monoxide leukoencephalopathy.

to a wide range of neurological symptoms, ranging from headaches, dizziness and altered mental status to coma. The basis for this is thought to be hypoxia. Carbon monoxide competes with oxygen for binding to hemoglobin (Hb) and once bound, shifts the oxyhemoglobin dissociation curve to the left, thus impairing off-loading of oxygen molecules, leading to hypoxia . A sizable minority of CO poison...