Nonbonded interactions in membrane active cyclic biopolymers. I. valinomycin-potassium ion complex
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Valinomycin-induced uptake of potassium in membrane vesicles from Escherichia coli.
Osmotically shocked Escherichia coli and membrane vesicle ghosts from E. coli cells have lost the ability to accumulate potassium by active transport. The addition of valinomycin to the membrane ghosts restores the capacity to accumulate radioactive (42)K and (86)Rb by a temperature- and energy-dependent process. Membrane vesicles prepared from mutants of E. coli altered in potassium transport ...
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Modeling metalloproteins often requires classical molecular dynamics (MD) simulations in order to capture their relevant motions, which in turn necessitates reliable descriptions of the metal centers involved. One of the most successful approaches to date is provided by the "cationic dummy model", where the positive charge of the metal ion is transferred toward dummy particles that are bonded t...
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Valinomycin is a depsipeptide antibiotic which selectively translocates potassium across biologic membranes. This potassium ionophore was observed to inhibit phytohemagglutinin-stimulated blastogenesis and proliferation in human lymphocytes. The effect was not due to toxicity to the cells, nor appeared to be due to the effects of valinomycin as an uncoupler of oxidative phosphorylation. Further...
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Several factors affecting K* transport by rabbit heart mitochondria were examined, using a K-sensitive electrode. The histone fractions f2a and j3-7 produced an energy-dependent efflux of K*. Inorganic phosphate was required for optimal activity; Km for phosphate was 60 /AM. Both rate and extent of K + efflux decreased as K concentration in the reaction medium was increased. The direction of va...
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Specific features of biopolymers which determine their functionality, in particular the catalytic activity of enzymes, are discussed. Electronicconformational interactions (Ed) are responsible for the most important properties of biopolymers. A survey of theoretical work is given, devoted to ECI, electron and atom transfer in enzymatic reactions. The qualitative methods of quantum chemistry are...
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ژورنال
عنوان ژورنال: International Journal of Quantum Chemistry
سال: 1975
ISSN: 0020-7608,1097-461X
DOI: 10.1002/qua.560090418