Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma
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چکیده
منابع مشابه
Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells
The robust glycolytic metabolism of glioblastoma multiforme (GBM) has proven them susceptible to increases in oxidative metabolism induced by the pyruvate mimetic dichloroacetate (DCA). Recent reports demonstrate that the anti-diabetic drug metformin enhances the damaging oxidative stress associated with DCA treatment in cancer cells. We sought to elucidate the role of metformin's reported acti...
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ژورنال
عنوان ژورنال: Frontiers in Nutrition
سال: 2018
ISSN: 2296-861X
DOI: 10.3389/fnut.2018.00091