Normobaric hyperoxia does not improve derangements in diffusion tensor imaging found distant from visible contusions following acute traumatic brain injury
نویسندگان
چکیده
منابع مشابه
Diffusion tensor imaging and traumatic brain injury.
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity in Americans, especially those under age 45. TBI accounts for more than 500,000 emergency department visits annually (Nirula et al., 2003). Closed head injury produces cerebral edema, hemorrhage, contusions, and ischemia. Diffuse axonal injury (DAI) is also a common consequence of head trauma, and results from rotational...
متن کاملNormobaric hyperoxia increases cerebral aerobic metabolism after traumatic brain injury
Objects: Traumatic brain injury (TBI) is associated with depressed aerobic metabolism and mitochondrial dysfunction. Normobaric hyperoxia (NBH) has been suggested as a treatment for TBI but human studies have produced equivocal results. We used brain tissue oxygen tension (PbrO2) measurement, cerebral microdialysis and near infrared spectroscopy to study the effects of NBH after TBI. We investi...
متن کاملHypothermia does not improve outcome from traumatic brain injury.
Therapeutic hypothermia is a potentially dangerous treatment with a very narrow therapeutic index. It is of proven benefit in certain conditions, including post ventricular fibrillation cardiac arrest and intermediate severity neonatal asphyxia. It is of no benefit and may cause harm in other contexts, such as elective neurovascular surgery. In traumatic brain injury there has been much provoca...
متن کاملDiffusion tensor imaging in mild traumatic brain injury litigation.
A growing body of literature addresses the application of diffusion tensor imaging (DTI) to traumatic brain injury (TBI). Most TBIs are of mild severity, and their diagnosis and prognosis are often challenging. These challenges may be exacerbated in medicolegal contexts, where plaintiffs seek to present objective evidence that supports a clinical diagnosis of mild (m)TBI. Because DTI permits qu...
متن کاملPathophysiological Concepts in Mild Traumatic Brain Injury: Diffusion Tensor Imaging Related to Acute Perfusion CT Imaging
BACKGROUND A subgroup of patients with mild traumatic brain injury (TBI) experiences residual symptoms interfering with their return to work. The pathophysiological substrate of the suboptimal outcome in these patients is a source of debate. OBJECTIVE To provide greater insight into the pathophysiological mechanisms of mild TBI. METHODS Diffusion tensor imaging (DTI) was performed during fo...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-12590-2