NOTCH, a new signaling pathway implicated in holoprosencephaly

NOTCH, a new signaling pathway implicated in holoprosencephaly.

Genetics of Holoprosencephaly (HPE), a congenital malformation of the developing human forebrain, is due to multiple genetic defects. Most genes that have been implicated in HPE belong to the sonic hedgehog signaling pathway. Here we describe a new candidate gene isolated from array comparative genomic hybridization redundant 6qter deletions, DELTA Like 1 (DLL1), which is a ligand of NOTCH. We ...

SnapShot: Notch Signaling Pathway

Notch Signaling Pathway: An Overview

Pancreatic cancer is the most aggressive malignant disease once it is diagnosed and it remains the fourth leading cause of cancer-related death in the U.S.A. Recent data indicates that the Notch signaling pathway plays an important role in the development and progression of pancreatic cancer. Emerging evidence also suggests that the activation of the Notch signaling pathway is mechanistically a...

Ubiquitinations in the Notch Signaling Pathway

The very conserved Notch pathway is used iteratively during development and adulthood to regulate cell fates. Notch activation relies on interactions between neighboring cells, through the binding of Notch receptors to their ligands, both transmembrane molecules. This inter-cellular contact initiates a cascade of events eventually transforming the cell surface receptor into a nuclear factor act...

Notch Signaling Pathway in Pancreatic Cancer Progression.

Pancreatic cancer (PC) is one of the highly aggressive malignances in the United States, suggesting that novel treatment strategies are required to achieve better treatment outcome in PC patients [1]. To achieve this goal, elucidation of underlying mechanism of development and progression of PC is necessary [1]. Although the molecular causes of PC are largely elusive, many studies have demonstr...