Novel 4(3H)-quinazolinones containing biologically active thiazole, pyridinone and chromene of expected antitumor and antifungal activities
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چکیده
منابع مشابه
Synthesis of Some Novel Sulfonamides Containing Biologically Active Alkanoic Acid, Acetamide, Thiazole, and Pyrrole Moieties of Expected Antitumor and Radiosensitizing Activities
Several novel N substituted sulfapyridine derivatives were synthesized by condensation of 2-ChloroN-(4-(N-pyridin-2-ylsulfamoyl)phenyl) acetamide 2 with different amino acids, amines, malononitrile, or ammonium thiocyanate to yield the corresponding alkanoic acid derivatives 3a-f, acetamide derivatives 48, pyrrole derivatives 912, and thiazolidinone derivative 13. The newly synthesized compound...
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2-Tosylacetonitrile (1) when reacted with α,β-unsaturated nitriles 2a-c or a mixture of formaldehyde and 3-amino-2-substituted-pent-2-endinitriles 6a,b yielded pyridine derivatives 3a-c and 9a,b, respectively, while when subjected to react with salicylaldehyde yielded chromene derivatives 4 and 5, subsequently. The behavior of thiocarbamoyl derivative 10 derived from 1 towards some α-halogenate...
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This study aimed for the synthesis of new heterocyclic compounds incorporating sulfamoyl moiety suitable for use as antimicrobial agents via a versatile, readily accessible N-[4-(aminosulfonyl)phenyl]-2-cyanoacetamide (3). The 2-pyridone derivatives were obtained via reaction of cyanoacetamide with acetylacetone or arylidenes malononitrile. Cycloaddition reaction of cyanoacetamide with salicyal...
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Indandione 1 was brominated to yield 2-bromoIndandione 2 which on further reacted with substituted thiocarbamides, carbamides, 2-aminothiophenols, 2-aminophenol and triazoles to furnished 3-substituted aniline-2-thia-4-aza-6,7-benzo-8-oxo-bicyclo [3.3.0]-1(5),3-octadiene 3, 3-substituted aniline-2-oxa-4-aza-6,7-benzo-8-oxo-bicyclo [3.3.0]-1(5),3-octadiene 4, 2-Thia-5-aza-9-oxo-3,4-(3’-substitut...
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Synthetic, structural and biological aspects of tetraazamacrocyclic complexes of Tin(II) have been described. The complexes were characterized by elemental analysis, molecular weight determination conductance measurements and electronic, infrared, H,C and Sn NMR spectral studies. Ligand and their unsymmetrical complexes have been tested for their antimicrobial effects on several pathogenic fung...
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ژورنال
عنوان ژورنال: European Journal of Chemistry
سال: 2011
ISSN: 2153-2257,2153-2249
DOI: 10.5155/eurjchem.2.4.455-462.171