Novel Approaches for the Treatment of Necrotic Immature Teeth Using Regenerative Endodontic Procedures: A Systematic Review and Meta-Analysis

The induction of a blood clot allowing apical revascularization with subsequent closure was reported several decades ago. Recent research has been focused on examining different scaffolds for regenerative endodontic procedures (REPs). aim this study to analyze the main outcomes in novel REP literature. search conducted using six databases. Only clinical trials aiming at treatment necrotic immature teeth were included. risk bias assessed by Risk Bias 2 tool. Additionally, quality included studies Grading Recommendations Assessment, Development, and Evaluation (GRADE) criteria. A summary individual meta-analysis performed. Relative risks data from success root length changes used studies, these combined random-effects meta-analysis. results reveal that showed no differences between patients who received or only REP. Limitations include certainty evidence low there significant heterogeneity studies. suggest remains as gold standard