Novel Bayesian classification models for predicting compounds blocking hERG potassium channels
نویسندگان
چکیده
منابع مشابه
Voltage-Dependent Gating of hERG Potassium Channels
The mechanisms by which voltage-gated channels sense changes in membrane voltage and energetically couple this with opening of the ion conducting pore has been the source of significant interest. In voltage-gated potassium (Kv) channels, much of our knowledge in this area comes from Shaker-type channels, for which voltage-dependent gating is quite rapid. In these channels, activation and deacti...
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OBJECTIVE The aryloxypropanolamine carvedilol is a multiple action cardiovascular drug with blocking effects on alpha-receptors, beta-receptors, Ca(2+)-channels, Na(+)-channels and various native cardiac K(+) channels, thereby prolonging the cardiac action potential. In a number of clinical trials with patients suffering from congestive heart failure, carvedilol appeared to be superior to other...
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The inactivation gating of hERG channels is important for the channel function and drug-channel interaction. Whereas hERG channels are highly selective for K+, we have found that inactivated hERG channels allow Na+ to permeate in the absence of K+. This provides a new way to directly monitor and investigate hERG inactivation. By using whole cell patch clamp method with an internal solution cont...
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Background: K+ channel toxins are essential tools for the first purifications, analysis of subunit structures and brain localization of voltage-gated K+ (Kv) channels. The effects of a lot of toxins on Kv are not fully known. Methods: Using whole-cell patch clamping technique the action of a series of toxins on Kv3.4 current in rat liver cells with expressed Kv3.4 channels (RLE) cloned cells wa...
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Railway infrastructures are among the most important national assets of countries. Most of the annual budget of infrastructure managers are spent on repairing, improving and maintaining railways. The best repair method should consider all economic and technical aspects of the problem. In recent years, data analysis of maintenance records has contributed significantly for minimizing the costs. B...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2014
ISSN: 1671-4083,1745-7254
DOI: 10.1038/aps.2014.35