NPT-IIb Inhibition Does Not Improve Hyperphosphatemia in CKD
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NPT-IIb Inhibition Does Not Improve Hyperphosphatemia in CKD
Introduction Serum phosphate levels are insufficiently controlled in many patients with end-stage renal disease (ESRD), and novel therapeutic strategies are needed. Blocking intestinal phosphate absorption mediated by sodium-dependent phosphate co-transporter type 2b (NPT-IIb) holds promise; thus, we evaluated the efficacy, safety, tolerability, and pharmacokinetics of the novel and specific sm...
متن کامل[Management of hyperphosphatemia in CKD].
2.2 Na DRC estágios III e IV, a ingestão dietética de P deverá ser mantida em valores que atendam a recomendação de proteínas entre 0,6 e 0,8 g/kg/dia, porém não superior a 700 mg/dia se o P estiver acima dos valores normais e/ou se o paratormônio (PTH) estiver acima do nível recomendado para o estágio da DRC (Opinião). 2.3 Na DRC estágio V D, a ingestão dietética de P deverá estar entre 800 e ...
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The incidence of cardiovascular events and mortality strongly correlates with serum phosphate in individuals with CKD. The Npt2b transporter contributes to maintaining phosphate homeostasis in the setting of normal renal function, but its role in CKD-associated hyperphosphatemia is not well understood. Here, we used adenine to induce uremia in both Npt2b-deficient and wild-type mice. Compared w...
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ژورنال
عنوان ژورنال: Kidney International Reports
سال: 2018
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2017.08.003