NT2 Derived Neuronal and Astrocytic Network Signalling
نویسندگان
چکیده
منابع مشابه
NT2 Derived Neuronal and Astrocytic Network Signalling
A major focus of stem cell research is the generation of neurons that may then be implanted to treat neurodegenerative diseases. However, a picture is emerging where astrocytes are partners to neurons in sustaining and modulating brain function. We therefore investigated the functional properties of NT2 derived astrocytes and neurons using electrophysiological and calcium imaging approaches. NT...
متن کاملBi-directional astrocytic regulation of neuronal activity within a network
The concept of a tripartite synapse holds that astrocytes can affect both the pre- and post-synaptic compartments through the Ca(2+)-dependent release of gliotransmitters. Because astrocytic Ca(2+) transients usually last for a few seconds, we assumed that astrocytic regulation of synaptic transmission may also occur on the scale of seconds. Here, we considered the basic physiological functions...
متن کاملMicroglia Control Neuronal Network Excitability via BDNF Signalling
Microglia-neuron interactions play a crucial role in several neurological disorders characterized by altered neural network excitability, such as epilepsy and neuropathic pain. While a series of potential messengers have been postulated as substrates of the communication between microglia and neurons, including cytokines, purines, prostaglandins, and nitric oxide, the specific links between mes...
متن کاملNeuronal-astrocytic interactions in glutamate metabolism.
17. Ji, Z., Aas, 1.-E., Laake, J., Walberg, F. and Ottersen, 0. P. (1991) J. Comp. Neurol. 307,296-310 18. Bramham, C. R., Torp, R., Zhang, N., StormMathisen, J. and Ottersen, 0. P. (1990) Neuroscience 39,405-417 19. Torp, R., Haug, F. M., T~nder , N., Zimmer, J. and Ottersen, 0. P. (1992) Neuroscience 46,807-823 20. Burger, P. M., Mehl, E., Cameron, P. L., Maycox, P. R., Baumert, M., Lottspeic...
متن کاملNeuronal activity regulates astrocytic Nrf2 signaling.
Nuclear factor erythroid 2-related factor 2 (Nrf2), the transcriptional master regulator of the stress-induced antioxidant response, plays a key role in neuronal resistance to oxidative stress and glutamate-induced excitotoxicity. Nrf2-mediated neuroprotection is primarily conferred by astrocytes both in vitro and in vivo, but little is known about physiologic signals that regulate neuronal and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0036098