Nuclear factor kB activity in patients with acute severe cholangitis
نویسندگان
چکیده
منابع مشابه
Establishment of a novel rat model of severe acute cholangitis
Objective(s):This study aimed to establish a novel non-binding, reversible rat model of acute cholangitis of the severe type (ACST). Materials and Methods:Twenty-six rats were randomly divided into the sham-operated group (n=13) and the ACST group (n=13). All rats were intubated with a modified catheter through the external jugular vein. The ACST model was established by ligation of the distal ...
متن کاملNuclear Factor-KB, an Unappreciated Tumor Suppressor
The notion that nuclear factor-KB (NF-KB) is a tumorpromoting transcription factor has become a widely accepted dogma in biology. However, recent findings suggest an inhibitory role for NF-KB in carcinogenesis and tumorigenesis. Although the tumor suppressor–like effect of NF-KB remains to be rigorously established by further studies using cellular and animal models, these latest findings warra...
متن کاملCircuitry of nuclear factor kB signaling
Acknowledgements We apologize to the many researchers whose work we have not been able to discuss in this limited review. A. H. thanks X.-F. Qin and T. H. Leung for longstanding collaboration and communication of unpublished results, G. Ghosh for figures of protein structures, and E. A. Komives, G. Ghosh, and V. Sivakumar for insightful discussions. Summary: Over the past few years, the transcr...
متن کاملNuclear factor (NF)-kB proteins: therapeutic targets*
N uclear factor (NF)-kB is a key player in the control of both innate and adaptive immunity. NF-kB proteins are present in the cytoplasm in association with inhibitory proteins called inhibitors of kB (IkBs). On activation by a large plethora of inducers, the IkB proteins are phosphorylated, ubiquitinated, and subsequently degraded in the proteasomes. Degradation of IkBs allows translocation of...
متن کاملNuclear factor-kB is constitutively activated in primitive human acute myelogenous leukemia cells
Human acute myelogenous leukemia (AML) is thought to arise from a rare population of malignant stem cells. Cells of this nature, herein referred to as leukemic stem cells (LSCs), have been documented for nearly all AML subtypes and appear to fulfill the criteria for stem cells in that they are self-renewing and give rise to the cells found in many leukemic populations. Because these cells are l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2002
ISSN: 1007-9327
DOI: 10.3748/wjg.v8.i2.346