Nucleic acid sequences coding for internal antisense peptides: are there implications for protein folding and evolution?
نویسندگان
چکیده
منابع مشابه
Efficient algorithms for folding and comparing nucleic acid sequences
Fast algorithms for analysing sequence data are presented. An algorithm for strict homologies finds all common subsequences of length greater than or equal to 6 in two given sequences. With it, nucleic acid pieces five thousand nucleotides long can be compared in five seconds on CDC 6600. Secondary structure algorithms generate the N most stable secondary structures of an RNA molecule, taking i...
متن کاملOn Low Energy Barrier Folding Pathways for Nucleic Acid Sequences
Secondary structure folding pathways correspond to the execution of DNA programs such as DNA strand displacement systems. It is helpful to understand the full diversity of features that such pathways can have, when designing novel folding pathways. In this work, we show that properties of folding pathways over a 2-base strand (a strand with either A and T, or C and G, but not all four bases) ma...
متن کاملCellular Morphology and Immunologic Properties of Escherichia coli Treated With Antimicrobial Antisense Peptide Nucleic Acid
Background & Objectives: Antisense peptide nucleic acids (PNA) that target growth essential genes show potent bactericidal properties without cell lysis. We considered the possibility that whether PNA treatment influence the bacteria total nucleic acids content and apply approach to develop a new delivery system to Dendritic cells (DCs). DCs are the most potent antigen presenting cells in th...
متن کاملNucleic Acid Therapeutics: Current Targets For Antisense Oligonucleotides And Ribozymes
Nucleic acids are becoming increasingly important as therapeutic molecules mainly for the ease with which specificity for a vast range of targets of these drugs is achieved. Yet the dose rates of several mg/kg are not easy to provide. Reform of drug policy has been suggested earlier to facilitate newer therapeutic strategies to be put to use. With the current technology, each mg of the unmodifi...
متن کاملC. Implications for Protein Folding
It has been evident for some time both that a random search through all conformations could not possibly explain protein folding (Levinthal, 1968) and also that the structures themselves show evidence of systematic local folding patterns. The consistent presence of domains in the larger proteins strongly suggests that they are folding units (Gratzer and Beaven, 1969; Wetlauter, 1973), and for s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1994
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/22.16.3373