NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity
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چکیده
منابع مشابه
NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity.
Nucleolar and spindle-associated protein (NuSAP) is a microtubule-associated protein that functions as a microtubule stabiliser. Depletion of NuSAP leads to severe mitotic defects, however the mechanism by which NuSAP regulates mitosis remains elusive. In this study, we identify the microtubule depolymeriser, mitotic centromere-associated kinesin (MCAK), as a novel binding partner of NuSAP. We ...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep18773