Nutritional, physiological and biochemical studies on thiamine.

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Studies on Thiamine Analocues

Several analogues of thiamine’ are known to compete with the vitamin when administered to animals. Thus, Woolley and White (1) have observed that pyrithiamine caused the manifestation of typical thiamine deficiency symptoms, which could be competitively overcome by the vitamin. The antivitamin effect of oxythiamine in mice has been reported by Soodak and Cerecedo (2). Cerecedo et al. (3, 4), co...

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Studies on the physiological functions of thiamine. I. The effects of thiamine deficiency and thiamine antagonists on the oxidation of alpha-keto acids by rat tissues.

Although thiamine has been known and studied for many years, there is still much we do not know about its physiological functions and mechanism of action in biological systems, particularly in animal tissues. Earlier workers have shown that thiamine diphosphate (cocarboxylase) functions as a coenzyme in the metabolism of pyruvate and a-ketoglutarate (l-9). However, the question regarding the im...

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Biochemical and histological studies on thiamine-deficient and ethanol-fed rats.

Rats were separated into four groups and four different liquid diets were given to each group. Group 1: thiamine-sufficient diet with no ethanol, group 2: thiamine-sufficient diet with ethanol, group 3: thiamine-deficient diet with no ethanol, group 4: thiamine-deficient diet with ethanol. After four weeks, all rats were fasted for 24 hr and then ethanol was given orally to every rat. After one...

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Studies on thiamine diphosphate-dependent enzymes.

The 3-deaza analogue of TPP (thiamine diphosphate), a close mimic of the ylid intermediate, has been synthesized and is an extremely potent inhibitor of a variety of TPP-dependent enzymes, binding much more tightly than TPP itself. Results using deazaTPP complexed with the E1 subunit of PDH (pyruvate dehydrogenase) have led to a novel proposal about the mechanism of this enzyme. The 2-substitut...

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Biochemical and Physiological Studies on the Effects of Senescence Leaves of Populus deltoides on Triticum vulgare

Triticum vulgare (Wheat) based products are the major dietary source of food in developing countries. In India, it grows in association with boundary plantations of Populus deltoids (poplar). During winter, poplar enters in dormancy which cause a heavy leaf fall at the time of wheat seed germination. Large number of poplar senescence leaves may adversely affect the wheat. Therefore, the present...

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ژورنال

عنوان ژورنال: Nippon Eiyo Shokuryo Gakkaishi

سال: 1988

ISSN: 1883-2849,0287-3516

DOI: 10.4327/jsnfs.41.165