Occurrence of overt seizures in comatose survivor patients treated with targeted temperature

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Occurrence of overt seizures in comatose survivor patients treated with targeted temperature

Background Unconscious patients after out-of-hospital cardiac arrest have a high risk of death. Therapeutic hypothermia is recommended by international resuscitation guidelines in order to attenuate secondary destructive physiological processes such as reperfusion injury, apoptosis, and cerebral edema. The target temperature to reach ranges between 32 and 34°C for at least 24 hr. Hypothermia ca...

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Targeted Temperature Management (TTM) for Comatose Survivors of Cardiac Arrest

Animal data has long supported the concept of managing temperature by inducing hypothermia following cardiac arrest to improve neurological outcome. In 2002 two landmark trials were published in the New England Journal of Medicine (NEJM); A European multicentre trial with a total of 136 patients compared therapeutic hypothermia of 32-34 for 24 hours to normothermia and demonstrated 55% vs 39% f...

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ژورنال

عنوان ژورنال: Brain and Behavior

سال: 2017

ISSN: 2162-3279

DOI: 10.1002/brb3.842