On permuted super-secondary structures of transmembrane β -barrel proteins
نویسندگان
چکیده
منابع مشابه
TMBpro: Secondary Structure, β-contact, and Tertiary Structure Prediction of Transmembrane β-Barrel Proteins
Motivation: Transmembrane -barrel (TMB) proteins are embedded in the outer membranes of mitochondria, Gram-negative bacteria, and chloroplasts. These proteins perform critical functions, including active ion-transport and passive nutrient intake. Therefore there is a need for accurate prediction of secondary and tertiary structure of TMB proteins. Traditional homology modeling methods, however,...
متن کاملBOCTOPUS: improved topology prediction of transmembrane β barrel proteins
MOTIVATION Transmembrane β barrel proteins (TMBs) are found in the outer membrane of Gram-negative bacteria, chloroplast and mitochondria. They play a major role in the translocation machinery, pore formation, membrane anchoring and ion exchange. TMBs are also promising targets for antimicrobial drugs and vaccines. Given the difficulty in membrane protein structure determination, computational ...
متن کاملPredicting three-dimensional structures of transmembrane domains of β-barrel membrane proteins.
β-Barrel membrane proteins are found in the outer membrane of gram-negative bacteria, mitochondria, and chloroplasts. They are important for pore formation, membrane anchoring, and enzyme activity. These proteins are also often responsible for bacterial virulence. Due to difficulties in experimental structure determination, they are sparsely represented in the protein structure databank. We hav...
متن کاملModeling and predicting super-secondary structures of transmembrane beta-barrel proteins. (Modélisation et prédiction de la structure super-secondaire des protéines transmembranaires canaux-beta)
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متن کاملPredicting giant transmembrane β-barrel architecture
MOTIVATION The β-barrel is a ubiquitous fold that is deployed to accomplish a wide variety of biological functions including membrane-embedded pores. Key influences of β-barrel lumen diameter include the number of β-strands (n) and the degree of shear (S), the latter value measuring the extent to which the β-sheet is tilted within the β-barrel. Notably, it has previously been reported that the ...
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ژورنال
عنوان ژورنال: Theoretical Computer Science
سال: 2014
ISSN: 0304-3975
DOI: 10.1016/j.tcs.2013.10.001