OncoKB: A Precision Oncology Knowledge Base
نویسندگان
چکیده
منابع مشابه
Precision oncology: an overview.
In this Special Series issue, Journal of Clinical Oncology presents a systematic assessment of cancer genomic information and its accelerating clinical impact. In the scientific literature and lay press, the relevant discipline is often called personalized, or precision, cancer medicine. The word personalized conveys the sense that cancer genomic data may facilitate rational treatment choices t...
متن کاملActionability and precision oncology.
Cancer is driven by molecular aberrations that allow oncogenic cells to thrive by growing and eventually metastasizing, and/or by alterations in the tumor or host that are permissive for immune evasion. The development and availability of clinical-grade molecular diagnostic tests that interrogate the genomic portfolio of each patient's tumor, together with the clinical development of a myriad o...
متن کاملFuture paradigms for precision oncology
Research has exposed cancer to be a heterogeneous disease with a high degree of inter-tumoral and intra-tumoral variability. Individual tumors have unique profiles, and these molecular signatures make the use of traditional histology-based treatments problematic. The conventional diagnostic categories, while necessary for care, thwart the use of molecular information for treatment as molecular ...
متن کاملPrecision medicine in pediatric oncology
PURPOSE OF REVIEW The current review describes recent advances and unique challenges in precision medicine for pediatric cancers and highlights clinical trials assessing the clinical impact of targeted therapy matched to molecular alterations identified by tumor profiling. RECENT FINDINGS Multiple prospective clinical sequencing studies in pediatric oncology have been reported in the last 2 y...
متن کاملAn Emerging Role for Radiation Oncology in Precision Oncology
Article history: Received 1 March 2016 Accepted 1 March 2016 Available online 4 March 2016 the precision of radiotherapy delivery (e.g. computational algorithms, IMRT, IGRT, SBRT); and3. Incorporationof novel radiosensitizing andmolecular targeting agents with radiation therapy to reduce mechanisms of radiation resistance (e.g. epithelial growth factor receptor inhibitors and RT in head and nec...
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ژورنال
عنوان ژورنال: JCO Precision Oncology
سال: 2017
ISSN: 2473-4284
DOI: 10.1200/po.17.00011