Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses
نویسندگان
چکیده
منابع مشابه
A Process Calculus for Molecular Interaction Maps
We present the MIM calculus, a modeling formalism with a strong biological basis, which provides biologically-meaningful operators for representing the interaction capabilities of molecular species. The operators of the calculus are inspired by the reaction symbols used in Molecular Interaction Maps (MIMs), a diagrammatic notation used by biologists. Models of the calculus can be easily derived...
متن کاملA Calculus for Molecular Interaction Maps
Molecular Interaction Maps are a graphical formalism used by biologists to describe complex interactions between molecules. We provide a formal description of MIMs using process algebras and determine its computational power.
متن کاملPattern Discovery in Breast Cancer Specific Protein Interaction Network
The interest in indentifying novel biomarkers for early stage breast cancer (BRCA) detection has become grown significantly in recent years. From a view of network biology, one of the emerging themes today is to re-characterize a protein's biological functions in its molecular network. Although many methods have been presented, including network-based gene ranking for molecular biomarker discov...
متن کاملMIMTool: A Tool for Drawing Molecular Interaction Maps
Background: To understand protein function, it is important to study proteinprotein interaction networks. These networks can be represented in network diagrams called protein interaction maps that can lead to better understanding by visualization. We address the problem of drawing of protein interactions in Kohn's Molecular Interaction Map (MIM) notation. Even though there are some existing too...
متن کاملBuilding Disease-Specific Drug-Protein Connectivity Maps from Molecular Interaction Networks and PubMed Abstracts
The recently proposed concept of molecular connectivity maps enables researchers to integrate experimental measurements of genes, proteins, metabolites, and drug compounds under similar biological conditions. The study of these maps provides opportunities for future toxicogenomics and drug discovery applications. We developed a computational framework to build disease-specific drug-protein conn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2020
ISSN: 1087-0156,1546-1696
DOI: 10.1038/s41587-020-0652-7