Onset of secondary progressive multiple sclerosis is not influenced by current relapsing multiple sclerosis therapies
نویسندگان
چکیده
منابع مشابه
Clinical characteristics of progressive relapsing multiple sclerosis.
OBJECTIVE Patients with progressive relapsing (PR) multiple sclerosis (MS) may accrue disability by incomplete recovery from acute exacerbations and by ongoing deterioration. In primary progressive (PP) MS, disability accumulates solely by continuous decline. Because it is the least common form of MS, there is scant information regarding the clinical characteristics of PRMS, but relapses are re...
متن کاملDefining secondary progressive multiple sclerosis.
A number of studies have been conducted with the onset of secondary progressive multiple sclerosis as an inclusion criterion or an outcome of interest. However, a standardized objective definition of secondary progressive multiple sclerosis has been lacking. The aim of this work was to evaluate the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis,...
متن کاملEmerging therapies for relapsing multiple sclerosis.
Six agents are currently approved by regulatory agencies to treat relapsing multiple sclerosis. Although these agents are effective and generally safe, some patients have continued disease activity or adverse effects. A sizable number of new agents are under investigation currently. This article reviews emerging agents that have shown promise in phase 2 trials.
متن کاملBeta‐interferon exposure and onset of secondary progressive multiple sclerosis
BACKGROUND AND PURPOSE Beta-interferons (IFNβ) are the most widely prescribed drugs for patients with multiple sclerosis (MS). However, whether or not treatment with IFNβ can delay secondary progressive MS (SPMS) onset remains unknown. Our aim was to examine the association between IFNβ exposure and SPMS onset in patients with relapsing-remitting MS (RRMS). METHODS A retrospective cohort stud...
متن کاملGray matter N-acetyl aspartate deficits in secondary progressive but not relapsing-remitting multiple sclerosis.
BACKGROUND AND PURPOSE Spectroscopic examination of multiple sclerosis (MS) patients has revealed abnormally low N-acetyl-aspartate (NAA) signal intensity, even in brain tissue that appears normal on high-resolution structural MR images but has yielded inconclusive evidence to distinguish the well-documented clinical differences between MS subtypes. This study used proton MR spectroscopic imagi...
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ژورنال
عنوان ژورنال: Multiple Sclerosis Journal - Experimental, Translational and Clinical
سال: 2018
ISSN: 2055-2173,2055-2173
DOI: 10.1177/2055217318783347