Opioid receptor and signal transduction.
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of opioid receptor signal transduction.
The analgesic and antidiarrhoeal uses of opium were known to the Sumerians and predynastic Egyptians. During 5000 years of medicinal use, opium has become associated with countries, cultures and prominent individuals, and through several modifications, remains an extensively used analgesic and addictive drug. Morphine, the principle active compound in opium, was first isolated by the German che...
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We demonstrated recently that opioid-induced activation of phospholipase D2 (PLD2) enhances (MOPr) and -opioid receptor endocytosis/recycling and thus reduces the development of opioid receptor desensitization and tolerance. However, the mechanistic basis for the PLD2-mediated induction of opioid receptor endocytosis is currently unknown. Here we show that PLD2-generated phosphatidic acid (PA) ...
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Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Pullman, Washington (R.M.Q.); Department of Pharmacology, University of California-Irvine College of Medicine, Irvine, California (F.J.E.); and Departments of Pharmacology (T.H.B., E.V., Y.H., K.H., S.C., C.S., W.R.R., H.I.Y.), Biochemistry (H.I.Y.), Medicine (W.R.R.), and Psychiatry (H.I.Y.) and the Program...
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Department of Pharmaceutical Sciences, Washington State University College of Pharmacy, Pullman, Washington (R.M.Q.); Department of Pharmacology, University of California-Irvine College of Medicine, Irvine, California (F.J.E.); and Departments of Pharmacology (T.H.B., E.V., Y.H., K.H., S.C., C.S., W.R.R., H.I.Y.), Biochemistry (H.I.Y.), Medicine (W.R.R.), and Psychiatry (H.I.Y.) and the Program...
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During the past two decades, studies describing the chemistry and biology of PAF have been extensive. This potent phosphoacylglycerol exhibits a wide variety of physiological and pathophysiological effects in various cells and tissues. PAF acts, through specific receptors and a variety of signal transduction systems, to elicit diverse biochemical responses. Several important future directions c...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1994
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)49940-x