Opposing Effects of Neuronal Activity on Structural Plasticity
نویسندگان
چکیده
منابع مشابه
Opposing Effects of Neuronal Activity on Structural Plasticity
The connectivity of the brain is continuously adjusted to new environmental influences by several activity-dependent adaptive processes. The most investigated adaptive mechanism is activity-dependent functional or synaptic plasticity regulating the transmission efficacy of existing synapses. Another important but less prominently discussed adaptive process is structural plasticity, which change...
متن کاملTitle: Reactive Oxygen Species Regulate Activity-Dependent Neuronal Structural Plasticity
1 in Drosophila 2 3 Authors: Matthew C. W. Oswald1*, Paul S. Brooks1, Maarten F. Zwart2, Amrita Mukherjee1, 4 Ryan J. H. West3, Khomgrit Morarach1, Sean T. Sweeney3, Matthias Landgraf1* 5 *Correspondence to: [email protected] and [email protected] 6 7 8 Affiliations: 9 1 University of Cambridge, Department of Zoology, Downing Street, Cambridge, CB2 3EJ, 10 United Kingdom 11 2 HHMI Janelia Researc...
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BACKGROUND Growing evidence suggests that sirtuins, a family of seven distinct NAD-dependent enzymes, are involved in the regulation of neuronal survival. Indeed, SIRT1 has been reported to protect against neuronal death, while SIRT2 promotes neurodegeneration. The effect of SIRTs 3-7 on the regulation of neuronal survival, if any, has yet to be reported. METHODOLOGY AND PRINCIPAL FINDINGS We...
متن کاملα- and βCaMKII Inverse Regulation by Neuronal Activity and Opposing Effects on Synaptic Strength
to the catalytic sites in the basal state. The binding of Ca 2ϩ /calmodulin releases this autoinhibition, allowing phosphorylation to take place at a critical threonine resi-a property that endows CaMKII with the ability Summary to decode Ca 2ϩ signals in a frequency-dependent man-We show that ␣ and CaMKII are inversely regulated Schulman et al., 1992; see also Eshete and Fields, 2001). by act...
متن کاملActivity-dependent structural plasticity.
Plasticity in the brain reaches far beyond a mere changing of synaptic strengths. Recent time-lapse imaging in the living brain reveals ongoing structural plasticity by forming or breaking of synapses, motile spines, and re-routing of axonal branches in the developing and adult brain. Some forms of structural plasticity do not follow Hebbian- or anti-Hebbian paradigms of plasticity but rather a...
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ژورنال
عنوان ژورنال: Frontiers in Neuroanatomy
سال: 2016
ISSN: 1662-5129
DOI: 10.3389/fnana.2016.00075