Opposite differential risks for autism and schizophrenia based on maternal age, paternal age, and parental age differences

Opposite differential risks for autism and schizophrenia based on maternal age, paternal age, and parental age differences

BACKGROUND AND OBJECTIVES Effects of maternal and paternal age on offspring autism and schizophrenia risks have been studied for over three decades, but inconsistent risks have often been found, precluding well-informed speculation on why these age-related risks might exist. METHODOLOGY To help clarify this situation we analysed a massive single population sample from Denmark including the fu...

Advancing paternal age and autism.

CONTEXT Maternal and paternal ages are associated with neurodevelopmental disorders. OBJECTIVE To examine the relationship between advancing paternal age at birth of offspring and their risk of autism spectrum disorder (ASD). DESIGN Historical population-based cohort study. SETTING Identification of ASD cases from the Israeli draft board medical registry. PARTICIPANTS We conducted a stu...

Maternal and paternal age and risk of autism spectrum disorders.

OBJECTIVE To explore the association between maternal and paternal age and risk of autism spectrum disorders (ASDs) in offspring. DESIGN Historical birth cohort study. SETTING Kaiser Permanente (KP) in Northern California. PARTICIPANTS All singleton children born at KP from January 1, 1995, to December 31, 1999, were included in the study. We identified 593 children who had ASD diagnoses ...

Differences in maternal and paternal age between schizophrenia and other psychiatric disorders.

Advanced parental age has been shown to increase offspring risk for a number of neuropsychiatric disorders including schizophrenia and Down's syndrome. Other psychiatric disorders have been less studied with respect to the effect of parental age on offspring risk. In this study we examine if advanced parental age increased risk for ICD-10 diagnoses. We hypothesized that advanced parental age wo...

Advancing Paternal Age and Risk of Autism