Optimized proteomic analysis of a mouse model of cerebellar dysfunction using amine-specific isobaric tags
نویسندگان
چکیده
منابع مشابه
Optimized proteomic analysis of a mouse model of cerebellar dysfunction using amine-specific isobaric tags.
Recent proteomic applications have demonstrated their potential for revealing the molecular mechanisms underlying neurodegeneration. The present study quantifies cerebellar protein changes in mice that are deficient in plasma membrane calcium ATPase 2 (PMCA2), an essential neuronal pump that extrudes calcium from cells and is abundantly expressed in Purkinje neurons. PMCA2-null mice display mot...
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ژورنال
عنوان ژورنال: PROTEOMICS
سال: 2006
ISSN: 1615-9853,1615-9861
DOI: 10.1002/pmic.200600026