Optimizing the spatial resolution of Channelrhodopsin-2 activation
نویسندگان
چکیده
منابع مشابه
Optimizing the spatial resolution of Channelrhodopsin-2 activation.
Over the past few years, the light-gated cation channel Channelrhodopsin-2 (ChR2) has seen a remarkable diversity of applications in neuroscience. However, commonly used wide-field illumination provides poor spatial selectivity for cell stimulation. We explored the potential of focal laser illumination to map photocurrents of individual neurons in sparsely transfected hippocampal slice cultures...
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For studying the function of specific neurons in their native circuitry, it is desired to precisely control their activity. This often requires dissection to allow accurate electrical stimulation or neurotransmitter application , and it is thus inherently difficult in live animals, especially in small model organisms. Here, we employed channelrhodopsin-2 (ChR2), a directly light-gated cation ch...
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ژورنال
عنوان ژورنال: Brain Cell Biology
سال: 2008
ISSN: 1559-7105,1559-7113
DOI: 10.1007/s11068-008-9025-8