Organic-Fluorous Phase Switches: A Fluorous Amine Scavenger for Purification in Solution Phase Parallel Synthesis

Fluorous synthesis: a fluorous-phase strategy for improving separation efficiency in organic synthesis.

Recovery and purification difficulties can limit the yield and utility of otherwise successful organic synthesis strategies. A "fluorous synthesis" approach is outlined in which organic molecules are rendered soluble in fluorocarbon solvents by attachment of a suitable fluorocarbon group. Fluorocarbon solvents are usually immiscible in organic solutions, and fluorous molecules partition out of ...

Plate-to-plate fluorous solid-phase extraction for solution-phase parallel synthesis.

A commercially available Argonaut VacMaster-96 plate-to-plate solid-phase extraction (SPE) station equipped with 24 FluoroFlash cartridges is employed for parallel purification of fluorous reaction mixtures. Each cartridge charged with 3 g of fluorous silica gel has the capability to produce up to 100 mg of purified small molecules. The 24-well receiving plate has a standard footprint that can ...

Fluorous biphase synthesis of a poly(p-phenyleneethynylene) and its fluorescent aqueous fluorous-phase emulsion.

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Fluorous methods for synthesis and separation of organic molecules*

Fluorous molecules partition out of an organic phase and into a fluorous (highly fluorinated) phase in a liquid–liquid extraction. New fluorous techniques allow simple yet substantive separations of organic reaction mixtures based on the presence or absence of a fluorous tag. Fluorous-tagged molecules can also be separated from nontagged molecules by solid phase extraction over fluorous reverse...

A fluorous-phase pummerer cyclative-capture strategy for the synthesis of nitrogen heterocycles.