Outcomes of additional local antibiotic to local analgesic and vasodilator in acute anal fissure - A randomized controlled study

Acute anal fissure is a common and painful condition of ano-rectal region characterized by tear in the anoderm causing pain during defecation. Mainstay its treatment pharmacotherapy with lifestyle modification. Current study was undertaken to evaluate role add-on local antimicrobial recovery relief symptoms acute comparison anesthetic vasodilator without any antimicrobial. It randomized, assessor-blinded, active-controlled clinical which data 68 eligible participants were analyzed. Participants both group received lignocaine nifedipine test (Group B) metronidazole ointment addition. Healing assessed examination Numeric Pain Rating Scale. Sample size calculated based upon result older pilot proportion Chi-square test. After 6 weeks treatment, 61 out (i.e., 89.7%) patients receiving recovered completely compared 75% comparator group. Reduction cessation bleeding also significantly better additional antibacterial. symptom addition antibacterial along anesthetic.