Oxidative damage and defense
نویسندگان
چکیده
منابع مشابه
UVA Irradiation of Dysplastic Keratinocytes: Oxidative Damage versus Antioxidant Defense
UVA affects epidermal cell physiology in a complex manner, but the harmful effects have been studied mainly in terms of DNA damage, mutagenesis and carcinogenesis. We investigated UVA effects on membrane integrity and antioxidant defense of dysplastic keratinocytes after one and two hours of irradiation, both immediately after exposure, and 24 h post-irradiation. To determine the UVA oxidative ...
متن کاملOxidative Stress and Antioxidant Defense
Reactive oxygen species (ROS) are produced by living organisms as a result of normal cellular metabolism and environmental factors, such as air pollutants or cigarette smoke. ROS are highly reactive molecules and can damage cell structures such as carbohydrates, nucleic acids, lipids, and proteins and alter their functions. The shift in the balance between oxidants and antioxidants in favor of ...
متن کاملEnrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage
Coenzyme Q10 (CoQ10) concentration in blood cells was analyzed by HPLC and compared to plasma concentration before, during, and after CoQ10 (3 mg/kg/day) supplementation to human probands. Lymphocyte DNA 8-hydroxydeoxy-guanosine (8-OHdG), a marker of oxidative stress, was analyzed by Comet assay. Subjects supplemented with CoQ10 showed a distinct response in plasma concentrations after 14 and 2...
متن کاملAntioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?
The oxidative damage theory of aging once seemed almost proven. Yet recently the buzzards have been assembling in the blue skies above it. New challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones. But is the theory really dead, or does it just need to be modified?
متن کاملAntioxidant defense and oxidative damage vary widely among high-altitude residents.
OBJECTIVES People living at high altitude experience unavoidable low oxygen levels (hypoxia). While acute hypoxia causes an increase in oxidative stress and damage despite higher antioxidant activity, the consequences of chronic hypoxia are poorly understood. The aim of the present study is to assess antioxidant activity and oxidative damage in high-altitude natives and upward migrants. METHO...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 1996
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/63.6.985