Oxygen sensors in hypoxic pulmonary vasoconstriction
نویسندگان
چکیده
منابع مشابه
Oxygen sensors in hypoxic pulmonary vasoconstriction.
Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism adapting lung perfusion to regional ventilation. Perturbations to HPV, such as those occurring in pneumonia, acute respiratory distress syndrome and liver failure, can result in arterial hypoxemia. Under conditions of general hypoxia, HPV increases pulmonary vascular resistance and thus causes acute pulmonary hypertension. Despi...
متن کاملHypoxic pulmonary vasoconstriction: redox events in oxygen sensing.
Recently, the mitochondria have become the focus of attention as the site of O(2) sensing underlying hypoxic pulmonary vasoconstriction (HPV). However, two disparate models have emerged to explain how mitochondria react to a decrease in Po(2). One model proposes that a drop in Po(2) decreases the rate of mitochondrial reactive oxygen species (ROS) generation, resulting in a decrease in oxidant ...
متن کاملHypoxic pulmonary vasoconstriction.
Humans encounter hypoxia throughout their lives. This occurs by destiny in utero, through disease, and by desire, in our quest for altitude. Hypoxic pulmonary vasoconstriction (HPV) is a widely conserved, homeostatic, vasomotor response of resistance pulmonary arteries to alveolar hypoxia. HPV mediates ventilation-perfusion matching and, by reducing shunt fraction, optimizes systemic Po(2). HPV...
متن کاملHypoxic pulmonary vasoconstriction.
Hypoxic pulmonary vasoconstriction is a local reflex in the lung that diverts blood away from poorly oxygenated regions. Improvements in understanding of modulators of this response have led to pharmacologic methods whereby V/Q matching may potentially be improved in certain types of pulmonary pathology and during anesthesia for thoracic surgical procedures.
متن کاملHypoxic pulmonary vasoconstriction: ups and downs of reactive oxygen species.
Reduction in alveolar oxygen tension causes reversible hypoxic pulmonary vasoconstriction (HPV), which is thought to serve as an adaptive mechanism for diverting blood flow from poorly ventilated to betterventilated regions of the lung to improve ventilationperfusion matching. Since first described by Von Euler and Liljestrand1 50 years ago, significant advances have been made in determining th...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2006
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2006.04.009