P-411 Cumulative live-birth rate after oocyte vitrification for fertility preservation (FP) in oncologic or benign conditions: a retrospective comparative monocentric study

Abstract Study question Does cumulative livebirth-rate (CLBR) after reutilization of vitrified oocytes differ between patients having undergone fertility preservation (FP) for oncologic (onco-FP) reason or benign conditions (benign-FP)? Summary answer Although CLBR per woman was lower in the onco-FP group, there no statistically significant association multivariate analysis and CLBR. What is known already Recent ESHRE guidelines reported oocyte vitrification controlled ovarian hyperstimulation (COH) as an established option FP. age at time remains main predictive factor success, several lines evidence suggest that use COH vitro maturation (IVM), well indication FP, particular type disease, may influence outcomes devitrification. The present investigation aimed clarifying this issue. design, size, duration Observational comparative, monocentric retrospective study including all reused, January 2014 December 2021, their 2013 2021. Women FP non-medical were excluded. Participants/materials, setting, methods Among 2201 oocytes, 94 (4.7%) returned reutilization. primary objective comparison (n = 48) benign-FP 46) groups. A logistic model performed. Factors associated with univariate included a model. secondary performed, comparing group 2 groups according to (Onco-COH, n 25) in-vitro (Onco-IVM, 23). Main results role chance Overall, women malignant diseases younger (median [IQR]: 34.0 y [31.0;37.0] vs. 36.5 [33.2;38.0], p 0.04) had fewer 6.0 [3.0;9.2] vs.15.5 [6.2;18.0]), < 0.001). 14.6% (7/48), 32.6% (15/46), respectively. In analysis, significantly when compared group: (OR [95%CI]: 0.35 [0.12;0.94], 0.04). However, difference did not reach significance 0.38 [0.09;1.51], 0.18). As expected, negatively 0.80 [0.67;0.92], 0.005), while number inseminated positively related 1.22 [1.08;1.40], 0.002). Unlike onco-COH, onco-IVM decrease (only COH), analysis: 8.7% 0.20 [0.03;0.80], 0.04), without 0.37 [0.04;2.16], 0.29).The livebirth rate (LBR) 2.1% subgroup (3 babies 141 thawed), 2.7% onco-COH (7 260 thawed) 3.7% (18 479 group. Limitations, reasons caution small size our population probably responsible lack statistical power. nature also be weakness. Furthermore, LBR analyzed age-adjustment. Wider implications findings This provides actual data on chances achieving vitrification, IVM context conditions. Trial registration applicable