P-53 Histopathologic evaluation of feline plasmacytic pododermatitis
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چکیده
منابع مشابه
P 53 ( Protein 53 kDa )
Protein Description 393 amino acids; 53 kDa phosphoprotein; contains, from N-term to C-term, a transactivation domain, a DNA-binding domain, nuclear localization signals and a tetramerization domain. Expression Widely expressed. Localisation Nucleus. Function Tumour suppressor gene; P53 is a transcriptional regulator acting as a guardian of the genome; in response to DNA damage, p53 is overexpr...
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Downlo PIM family of serine threonine protein kinases plays an important role in regulating both the growth and rmation of malignant cells. However, in a cell line–dependent manner, overexpression of PIM1 can t cell and tumor growth. In 22Rv1 human prostate cells, but not in Du145 or RWPE-2, PIM1 oversion was associated with marked increases in cellular senescence, as shown by changes in the le...
متن کاملMole Spo p 53
acrjourna h levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, ting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. t this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two ndent lines of transgenic mice, Mdm4 and Mdm4, developed spontaneous tumors, the most prevf ...
متن کاملDifferential regulation of p 53 target
promoters Regulation of the p53 transcriptional response by structurally diverse core service Email alerting click here top right corner of the article or Receive free email alerts when new articles cite this article-sign up in the box at the
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ژورنال
عنوان ژورنال: Veterinary Dermatology
سال: 2004
ISSN: 0959-4493,1365-3164
DOI: 10.1111/j.1365-3164.2004.00414_53.x