P002 CPAP therapy compliance and changes in cognitive function in patients with obstructive sleep apnoea
نویسندگان
چکیده
Abstract Aims Obstructive sleep apnoea (OSA) has been implicated in the pathophysiology of Alzheimer’s disease (AD). Intermittent hypoxia and arousals may contribute to mechanisms leading accumulation amyloid beta plaques intraneuronal neurofibrillary tangles seen AD. Treatment with Continuous Positive Airway Pressure (CPAP) improves symptoms cardiovascular sequalae OSA, also mitigate progression We investigated, patients moderate severe whether CPAP compliance altered cognitive test scores. Methods Cognitive testing Addenbrooke’s Examination-Revised Version (ACE-R) was performed before commencing repeated after 3 5 years. Student’s independent t-test used compare changes ACE-R between compliant non-complaint groups based on usage greater than 4 hours/day. Results 30 subjects, mean age 67 years (SD=6.4), had baseline 90 (SD=4.75). At follow up, treatment subjects demonstrated improvement scores memory visuospatial domains a 1.5 points p=0.01 95% CI [0.33, 2.67], cognition 0.95 [0.23, 1.7]. Scores for non-compliant showed no significant difference over time. Conclusion Sustained use time results statistically scores, subdomains cognition. However, clinical significance these findings is unclear requires further research, as remained normative range.
منابع مشابه
Long-term CPAP Compliance in Women with Obstructive Sleep Apnoea
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ژورنال
عنوان ژورنال: Sleep advances
سال: 2022
ISSN: ['2632-5012']
DOI: https://doi.org/10.1093/sleepadvances/zpac029.075