P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis?
نویسندگان
چکیده
منابع مشابه
P2X7 receptor activation regulates rapid unconventional export of transglutaminase-2
Transglutaminases (denoted TG or TGM) are externalized from cells via an unknown unconventional secretory pathway. Here, we show for the first time that purinergic signaling regulates active secretion of TG2 (also known as TGM2), an enzyme with a pivotal role in stabilizing extracellular matrices and modulating cell-matrix interactions in tissue repair. Extracellular ATP promotes TG2 secretion ...
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Astrocyte glutamate release can modulate synaptic activity and participate in brain intercellular signaling. P2X7 receptors form large ion channels when activated by ATP or other ligands. Here we show that P2X7 receptors provide a route for excitatory amino acid release from astrocytes. Studies were performed using murine cortical astrocyte cultures. ATP produced an inward current in patch-clam...
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ژورنال
عنوان ژورنال: Amino Acids
سال: 2016
ISSN: 0939-4451,1438-2199
DOI: 10.1007/s00726-016-2319-8