P368 The presence of extra-intestinal manifestations is associated with poor prognosis in acute severe ulcerative colitis: A KASID multicenter study

Abstract Background Many patients with inflammatory bowel disease experience extra-intestinal manifestations (EIM)s. The presence of EIMs is related to activity. Acute severe ulcerative colitis (ASUC) associated a high burden. However, there are insufficient studies on the relation between and prognosis exacerbation colitis. This study was conducted elucidate correlation ASUC. Methods We retrospectively included who were hospitalized at four tertiary medical centers for ASUC management January 2015 December 2020, data underlying disease, activity, EIMs, colectomy, treatment method, readmission due aggravation checked. Results A total 145 (mean age 44.4 years, 68 women) investigated. initial partial Mayo score, endoscopy sub-score, endoscopic severity index 7.6±0.8%, 2.7±0.5, 6.0±1.4%, respectively. expressed in 10.3% (15/145) patients. most common type peripheral articular (46.7%) followed by skin lesions (20%) axial (13.3%). group younger had higher proportion women than without (39.4 versus 45 p=0.03), longer duration (5.8 3.5 p=0.02). sub-score (2.9 vs. 2.7, p<0.01) score (7.9 7.6, also group. length hospital stay (25.5 days 13.8 days, p<0.01). response rate lower (71.4% 95.5%, p<0.01), more rescue therapy (28.6% 4.5%, performed. colectomy admission (13.3% 0.8%, Patients showed tendency visit re-exacerbation after discharge (p=0.07, HR 2.10 CI: 0.93 – 4.76). Conclusion suggested poor