Paraoxonase Gene Polymorphisms and Aortic Calcification
نویسندگان
چکیده
منابع مشابه
Alzheimer’s Disease and Paraoxonase 1 (PON1) Gene Polymorphisms
BACKGROUND Some studies have indicated that human paraoxonase 1 (PON1) activity shows a polymorphic distribution. The aim of this study was to determine the distribution of PON1 polymorphism in patients with Alzheimer's disease in Gorgan and compare it with a healthy control group. METHOD The study included 100 healthy individuals and 50 patients. Enzyme activity and genetic polymorphism of P...
متن کاملParaoxonase 1 gene polymorphisms and enzyme activities in diabetes mellitus.
Paraoxonase 1 (PON1), an antioxidant enzyme closely associated with HDL (high-density lipoproteins), preserves LDL (low-density lipoproteins) against oxidation. Less protection may be therefore supposed by decreased PON1 activity. This study was undertaken to investigate the association of PON1 gene polymorphisms with diabetic angiopathy and to evaluate the relationship of these polymorphisms w...
متن کاملPromoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations.
Paraoxonase (PON) is a serum enzyme with a wide species distribution. It protects lipoproteins from toxic oxidative modifications and is an antiatherogenic mechanism of major potential. Activity levels of PON are major determinants of the protective function; consequently, factors that influence PON levels are of particular relevance. The present study has identified 3 polymorphisms in the prom...
متن کاملAssociation of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy.
Emerging reports have revealed a potential association of paraoxonase (PON) gene polymorphisms with diabetic nephropathy (DN) and diabetic retinopathy (DR). However, the identification of susceptible genes and the quantification of associated risks are elusive owing to a lack of reproducibility. Therefore, a meta‑analysis was conducted in the present study to improve the understanding of the ef...
متن کاملEffects of paraoxonase 1 gene polymorphisms on heart diseases
BACKGROUND Associations between paraoxonase 1 (PON1) gene polymorphisms and heart diseases (HD) risk remain inconsistent. In order to obtain address this issue we performed a meta-analysis to assess the association between the L55M and Q192R polymorphisms of PON1 gene and heart diseases risk. METHODS Relevant studies were enrolled by searching databases systematically. Odds ratios (ORs) with ...
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ژورنال
عنوان ژورنال: International Journal of Gerontology
سال: 2010
ISSN: 1873-9598
DOI: 10.1016/j.ijge.2010.11.006