Parthenolide inhibits hydrogen peroxide‑induced osteoblast apoptosis
نویسندگان
چکیده
منابع مشابه
Parthenolide inhibits tubulin carboxypeptidase activity.
Microtubules are centrally involved in cell division, being the principal components of mitotic spindle. Tubulin, the constituent of microtubules, can be cyclically modified on its alpha-subunit by enzymatic removal of the COOH-terminal tyrosine residue by an ill-defined tubulin carboxypeptidase (TCP) and its readdition by tubulin tyrosine ligase (TTL). We and others have previously shown that ...
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Diabetic osteoporosis represents a serious health condition with increasing incidence. Previous studies have shown that microRNA (miR)-335-5p is highly expressed in MC3T3-E1 osteoblasts and promotes their differentiation via downregulating the expression of dickkopf‑1 (DKK1). The present study investigated the effects of miR‑335‑5p on apoptosis of osteoblasts induced by high glucose (HG), as we...
متن کاملHydrogen peroxide-induced apoptosis of human lens epithelial cells is inhibited by parthenolide.
AIM To explore the effect of parthenolide on hydrogen peroxide (H2O2)-induced apoptosis in human lens epithelial (HLE) cells. METHODS The morphology and number of apoptotic HLE cells were assessed using light microscopy and flow cytometry. Cell viability was tested by MTS assay. In addition, the expression of related proteins was measured by Western blot assay. RESULTS Apoptosis of HLE cell...
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Objective(s):MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. They have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (CKD). In the present study, we elucidated the role of microR...
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Cholangiocarcinomas are intrahepatic bile duct carcinomas that are known to have a poor prognosis. Sesquiterpene lactone parthenolide, which is the principal active component in medicinal plants, has been used to treat tumors. Parthenolide effectively induced apoptosis in all four cholangiocarcinoma cell lines in a dose-dependent manner. However, the sarcomatous SCK cells were more sensitive to...
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ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2018
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2018.8908