Partial Purification of Plasma Thromboplastin Antecedent (Factor XI) and its Activation by Trypsin
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Partial purification of plasma thromboplastin antecedent (factor XI) and its activation by trypsin.
A persistent puzzle in our understanding of hemostasis has been the absence of hemorrhagic symptoms in the majority of patients with Hageman trait, the hereditary deficiency of Hageman factor (factor XII). One proposed hypothesis is that alternative mechanisms exist in blood through which plasma thromboplastin antecedent (PTA, factor XI) can become active in the absence of Hageman factor. In or...
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A specific, sensitive, and reproducible radioimmunoassay for human plasma thromboplastin antecedent (PTA, factor Xl) has been developed with purified PTA and monospecific rabbit antiserum. Precise measurements of PTA antigen were possible for concentrations as low as 0.3% of that in normal pooled plasma. Normal plasma contained approximately 6 zg PTA/mI. A good correlation (correlation coeffici...
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By W. Angus Muir and Oscar D. Ratnoff P LASMA TH ROM BOPLASTIN antecedent (PTA, Factor X I) deficiency is an inherited disorder of blood coagulation characterized by a defect of the intrinsic pathway of thrombin formation and a mild to moderate bleeding tendency. Since the original description by Rosenthal, Dreskin, and Rosenthal,’ it has been reported in this country and in Europe to occur wit...
متن کاملPlasma thromboplastin antecedent (PTA, factor XI): a specific and sensitive radioimmunoassay.
A specific, sensitive, and reproducible radioimmunoassay for human plasma thromboplastin antecedent (PTA, factor XI) has been developed with purified PTA and monospecific rabbit antiserum. Precise measurements of PTA antigen were possible for concentrations as low as 0.3% of that in normal pooled plasma. Normal plasma contained approximately 6 microgram PTA/ml. A good correlation (correlation c...
متن کاملActivation of Bovine Factor IX (Christmas Factor) by Factor XI, (Activated Plasma Thromboplastin Antecedent) and a Protease from Russell’s Viper Venom*
Bovine factor IX (Christmas factor) is a coagulation protein present in plasma in a precursor or inactive form. It is a glycoprotein (M, = 55,000) composed of a single polypeptide chain. Factor IX in the presence of calcium ions is converted to factor IX, by factor XI, (activated plasma thromboplastin antecedent) or a protease present in Russell’s viper venom. The activation of factor IX by the...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1973
ISSN: 0021-9738
DOI: 10.1172/jci107249