PAS kinase: Integrating nutrient sensing with nutrient partitioning
نویسندگان
چکیده
منابع مشابه
PAS kinase: integrating nutrient sensing with nutrient partitioning.
Recent data suggests that PAS kinase acts as a signal integrator to adjust metabolic behavior in response to nutrient conditions. Specifically, PAS kinase controls the partitioning of nutrient resources between the myriad of possible fates. In this capacity, PAS kinase elicits a pro-growth program, which includes both signaling and metabolic control, both in yeast and in mammals. We propose tha...
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Cells have several sensory systems that detect energy and metabolic status and adjust flux through metabolic pathways accordingly. Many of these sensors and signaling pathways are conserved from yeast to mammals. In this review, we bring together information about five different nutrient-sensing pathways (AMP kinase, mTOR, PAS kinase, hexosamine biosynthesis and Sir2), highlighting their simila...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2012
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2011.12.007