Past times: The efficiency of enzyme catalysis
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چکیده
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15 صفحه اولConcept of Enzyme Catalysis
A typical enzyme reaction runs through several steps. The structure of the enzymesubstrate intermediate in each step is reorganized to an optimal state to pass the next transition state. A very limited number of basic chemical catalytic principles are used in each transition state, and this is accomplished by a limited number of functional groups like amino acid side chains. Various methods of ...
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Internal protein dynamics are intimately connected to enzymatic catalysis. However, enzyme motions linked to substrate turnover remain largely unknown. We have studied dynamics of an enzyme during catalysis at atomic resolution using nuclear magnetic resonance relaxation methods. During catalytic action of the enzyme cyclophilin A, we detect conformational fluctuations of the active site that o...
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ferable struggle to live and the necessity of preserving a healthy verile stock probably stated their attitude to their weaker brethren. Many peoples including the Spartans, elts and Romans, for instance, required all newly born infants to submit to searching ?Crutiny to exclude evidence of poor development and physical defect. Some even lri:iposed rigorous tests of fitness, as for example the ...
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ژورنال
عنوان ژورنال: The Biochemist
سال: 2003
ISSN: 0954-982X,1740-1194
DOI: 10.1042/bio02504052