PATHOGENETICALLY DIRECTED METHOD OF PREVENTION AND TREATMENT OF AGE-MACULAR DEGENERATION

Background. Age-related macular degeneration is one of the most common causes blindness in developed countries, especially people over 60 years old. The incidence AMD projected to increase 288 million 2040 compared 196 2020. Cardiovascular factors, smoking, alcohol consumption, overweight, genetic and metabolic disorders are risk factors for development AMD. There lipid metabolism, as well hyperreactivity platelet purine receptors may be associated with progression AREDS2 formula currently used treat New therapeutic strategies aimed correct needed decrease late stages AMD.
 Aim: investigate effectiveness improving pathogenetically directed method prevention treatment age-related degeneration.
 Materials methods. We observed 40 patients (80 eyes), aged 50-85 years, category 3 (intermediate AMD), who were divided into 2 groups. main group included 20 (40 14 women 6 men, have prescribed a complex drug according standard scheme, fenofibrate (200 mg) clopidogrel bisulfate (75 mg). control 13 7 men. These received treatment. Progression was evaluated results OCT area AREDS classification corrected visual acuity (CVA). observation period years.
 Results. No signs noted both groups within months from start therapy. In group, disease recorded after 1 year defined criteria. Changes 7,5% CVA- 5%. extended regimen, follow-up, 2,5% cases, but there no worsening CVA. After observation, OST by 50% less than group. According CVA, detected 15% 30% group.
 Conclusions. This study complemented already existing preventive