Paths of antibiotic resistance
نویسندگان
چکیده
منابع مشابه
Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance.
Alternating antibiotic therapy, in which pairs of drugs are cycled during treatment, has been suggested as a means to inhibit the evolution of de novo resistance while avoiding the toxicity associated with more traditional combination therapy. However, it remains unclear under which conditions and by what means such alternating treatments impede the evolution of resistance. Here, we tracked mul...
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Antibiotic use is the main driver in the emergence of antibiotic resistance. Another unexplored possibility is that resistance evolves coincidentally in response to other selective pressures. We show that selection in the absence of antibiotics can coselect for decreased susceptibility to several antibiotics. Thus, genetic adaptation of bacteria to natural environments may drive resistance evol...
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Antibiotic resistance is an ongoing evolutionary process that has been the concern of infectious disease specialists since antibiotic use gained popularity. Antibiotic resistance is not a concern of the public as reflected by their desire for antibiotics whenever illness occurs. Patients can and do pressure their physicians for antibiotics ; 12 million antibiotic prescriptions were filled for u...
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are resistant to one of the first-line drugs (rifampicin, isoniazid, ethambutol, streptomycin).5 Resistance is emerging due to the increasing exposure of microorganisms to antimicrobial agents. Exposure of microbes to antimicrobials tempt them to develop strategies to survive in the hostile environment and become resistant. Pressure on the bacteria to mutate and become “hardy” develops due to (...
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Antibiotics are developed to kill microorganisms; however, microorganisms develop and disseminate resistance as a reaction to antimicrobials in accordance with the laws of evolution and natural selection. Resistant and multidrug-resistant bacterial infections comprise a great problem in both the community and hospital setting. Increasing values of health expenditures, including antibiotics, is ...
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2012
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg3171