Patterns of nuclear fluorescence and DNA-binding activity.
نویسندگان
چکیده
منابع مشابه
Patterns of nuclear fluorescence and DNA-binding activity.
Sera from patients with systemic lupus erythematosus (SLE) and other connective tissue diseases have been demonstrated to contain a variety of antinuclear antibodies. Antibodies to native DNA appear to be present only in sera from patients with clinically active SLE. These antibodies have been detected by a variety of techniques, such as precipitation in agar (Seligmann, 1957), complement fixat...
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We have developed a method for the rapid extraction of nuclear proteins from cultured cells. The ammonium sulfate method described here extracts larger quantities of proteins that retain DNA binding activity than the modified Dignam method and another popular method used for the extraction of transcription factors. The ammonium sulfate method is rapid and can be used to process a large number o...
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Accurate cellular localization plays a crucial role in the effective function of most signaling proteins, and nuclear trafficking is central to the function of transcription factors. IFN regulatory factor (IRF)3 is a master transcription factor responsible for the induction of type I IFN, which plays a crucial role in host antiviral innate immune responses. However, the mechanisms for control a...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1973
ISSN: 0003-4967
DOI: 10.1136/ard.32.4.337