PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions
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چکیده
منابع مشابه
PCNA dependent cellular activities tolerate dramatic perturbations in PCNA client interactions
Proliferating cell nuclear antigen (PCNA) is an essential cofactor for DNA replication and repair, recruiting multiple proteins to their sites of action. We examined the effects of the PCNAS228I mutation that causes PCNA-associated DNA repair disorder (PARD). Cells from individuals affected by PARD are sensitive to the PCNA inhibitors T3 and T2AA, showing that the S228I mutation has consequence...
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Proliferating cell nuclear antigen (PCNA), commonly known as a nuclear protein essential for regulation of DNA replication, DNA repair, and epigenetics, has recently been associated with multiple cytosolic functions. Many proteins containing one of the two known PCNA-interacting motifs, the AlkB homologue 2 PCNA interacting motif (APIM) and the PCNA-interacting peptide (PIP)-box, are considered...
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Recent work has shown that the proliferating cell nuclear antigen (PCNA) is an essential component for the replication of the eucaryotic virus, SV40, in a human cell extract. This is due to its interaction with a hitherto overlooked DNA polymerase (pol <5), and this discovery has brought these two proteins under the scrutiny of those working in the cell cycle, replication and DNA polymerase fie...
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متن کاملThe archaeal PCNA proteins.
PCNA (proliferating-cell nuclear antigen) is a ring-shaped protein that encircles duplex DNA and plays an essential role in many DNA metabolic processes. The PCNA protein interacts with a large number of cellular factors and modulates their enzymatic activities. In the present paper, we summarize the structures, functions and interactions of the archaeal PCNA proteins.
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ژورنال
عنوان ژورنال: DNA Repair
سال: 2017
ISSN: 1568-7864
DOI: 10.1016/j.dnarep.2016.12.003